Revista Cubana de Farmacia
versão ISSN 0034-7515
RODRIGUEZ AMADO, Jesús Rafael; LAFOURCADE PRADA, Ariadna e ESCALONA ARRANZ, Julio César. Formulation of tamarind tablets using the wet granulation method. Rev Cubana Farm [online]. 2011, vol.45, n.3, pp. 414-422. ISSN 0034-7515.
The objective of this paper was to prepare tablets using Tamarindus indica L. leaf soft extract as active ingredient. The classic method for manufacturing tablets by means of wet granulation at lab scale was used. Three formulations were prepared in which the quantities of excipients lactose, Aerosil®, microcrystalline cellulose and croscarmellose sodium varied. Three formulations were obtained with adequate characteristics in the manufacturing process but the number 3 exhibited the best technological quality. For further optimization of this formulation, the effect of the excipient must be studied because there was direct relationship between the added amount of disintegrant and the disintegration time.
Palavras-chave : Tamarind; tablets; wet granulation; soft extract.