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Revista Cubana de Farmacia

versión impresa ISSN 0034-7515

Resumen

CURIEL HERNANDEZ, Harold; VELEZ CASTRO, Hermán  y  LORA GARCIA, Janet. Quantitative determination through capillary zone electrophoresis of mangiferin in 300 mg VIMANG® tablets. Rev Cubana Farm [online]. 2011, vol.45, n.3, pp.423-430. ISSN 0034-7515.

Mangiferin was selected as marker in the quality control of active principle VIMANG® and its formulations, which have been used as nutritional supplement, cosmetic, and phytomedication. This paper was aimed at validating the capillary electrophoresis method for the quantitative analysis of mangiferin in the pharmaceutical formulation 300 mg VIMANG® tablets. The specificity, linearity, accuracy and precision were assessed. The results showed the method specificity owing to lack of interference by the excipients or their degradation products. Linearity showed a correlation coefficient of 0.9979 in the studied concentration range. The variation coefficients for repeatability and intermediate precision were less than 2 %. Accuracy reached a recovery rate of 100.20 % that is not statistically different from 100 %. It may be concluded that the validated method is specific, linear, precise and accurate and could be an advantageous alternative to the high resolution liquid chromatography method used at the lab setting.

Palabras clave : mangiferin; VIMANG®; capillary electrophoresis; UV detection; control zone electrophoresis.

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