SciELO - Scientific Electronic Library Online

vol.46 issue1Comparison between two murine biomodles (Balb/c mice and Sprague Dawley rats) in a transplacental micronucleus assayCharacterization of community pharmacies in Santa Clara city for the implementation of drug dispensing author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Revista Cubana de Farmacia

Print version ISSN 0034-7515


TOBON MARULANDA, Flor Ángela  and  VALLEJO MAYA, Julián. Ocular tolerance profile of a cosmetic product for babies in vivo. Rev Cubana Farm [online]. 2012, vol.46, n.1, pp.49-60. ISSN 0034-7515.

Introduction: the study that is performed for health registration before marketing any cosmetic product assures its safety and efficacy to prevent a public health problem. Objective: to describe the possible eye risk caused by a shampoo for babies through in vivo testing. Methods: a clinical exploratory and hermeneutic study based on direct macroscopic observation of clinical effects; determination of average effects in 6 rabbits by the OECD value scale and a histopathological study of a sample of eye tissue. Results: fifty percent of rabbits showed level 1 ocular injury; 16.67 % suffered level 2 whereas 33.33 % had level 3. None of the animals reached level 4 (maximum level in injuries). The analysis of the average clinical effects and the histopathological study confirmed the sensitivity of the rabbit as experimental reference that may be applicable to babies. Conclusions: the shampoo might cause mild eye effects; however the possible ocular risk must be stated until such time as the safety of the product is proven.

Keywords : prevention; public health; cosmetic; eye irritation; babies.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License