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Revista Cubana de Farmacia

versión impresa ISSN 0034-7515


CASTANO ARAUJO, Olga et al. The redox state of VIH/AIDS patients suffering chronic renal failure and undergoing hemodyalisis. Rev Cubana Farm [online]. 2012, vol.46, n.4, pp.410-424. ISSN 0034-7515.

Introduction: the altered redox balance in chronic renal failure has been considered a contributing factor to morbidity and mortality from this disease and as an AIDS progression-associated factor. Objective: to assess the redox state in HIV patients suffering chronic renal failure that requires haemodialysis. Methods: a case-control study was conducted in 20 HIV/AIDS patients with chronic renal failure and in 40 apparently healthy individuals. Estimations of malonildialdehyde, gluthatione, superoxide dismutase, catalase, advanced products from protein oxidation, hydroperoxides and peroxidation potentials, as well as progression markers such as T CD4+ lymphocyte count, viral load and a series of hemochemical and hematological determinations were all made. The analysis was made before, 30 minutes and 240 min after the dialysis. The assumptions of variance equality and variable normality were verified, and accordingly, a parametric or non-parametric test was applied. The result was significant for p< 0,05. Results: the redox state indicators were found to be altered in the studied patients when they were compared to the supposedly healthy group before hemodialysis. It was shown that the values of malondialdehyde, advanced products from protein oxidation, superoxide dismutase were high and significant whereas catalase and gluthatione had lower values after 240 minutes of dialysis, except for hydroperoxides that did not change. The plasma viral load decreased significantly in this process. Conclusions: the results suggested that the dialysis in this type of patients favors the oxidative stress, together with the reduction of the plasma viral load. The study grants some methodological value to the management of these patients and to the search for a better quality of life.

Palabras clave : hemodyalisis; HIV; oxidative stress; malondialdehyde.

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