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Revista Cubana de Farmacia

versión impresa ISSN 0034-7515


SOLER ROGER, Dulce María et al. Long-term stability of a Rhizophora mangle L. (red mangrove) gel for wounds and burns. Rev Cubana Farm [online]. 2012, vol.46, n.4, pp.446-456. ISSN 0034-7515.

Objective: to evaluate the long-term stability of a gel obtained from the aqueous extract of the Rhizophora mangle L. (red mangrove) bark. Methods: the three gel pilot batches (GM01, GM02 and GM03) were stored under refrigeration (5 ± 3 °C) for 12 months. Physical-chemical and microbiological evaluations were made at the beginning and after 3, 6, 9 and 12 months. Results: All these batches kept their appearance of homogeneous, viscous, lump-free and bright gels with dark reddish-brown color and wide areas of extensibility. The pH ranged 6 to 7 and the rheology reflected a non-Newtonian Herschel Bulkley-type fluid with modified potential at all evaluated times. The three batches met the established microbial limit and the minimum inhibitory concentration (MIC) of 8 to 10 mg / mL and the tannin concentration of 13 to 30 mg/g. Conclusions: it was demonstrated that all the gel batches were stable during the long-term stability study, so it was suggested that the gel should be stored at 2-8 °C for one year.

Palabras clave : long-term stability; Rhizophora mangle L.; red mangrove; gel.

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