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Revista Cubana de Farmacia

Print version ISSN 0034-7515


GONZALEZ FERRER, Lázara Sulin  and  SAME PEREZ, Ana María. Design and validation of a spectrophotometric method for the quality control of Furvinol. Rev Cubana Farm [online]. 2013, vol.47, n.4, pp.446-454. ISSN 0034-7515.

Introduction: Furvinol is a Cuban ophthalmic ointment for veterinary purposes. It is used in the external treatment of ocular infections in animals due to its wide spectrum antibacterial action. Its active principle derived from the sugar cane known as Furvina or G-1. Objective: to develop a method based on UV Vis spectrophotometry for application in quality control of Furvinol. Methods: a quick procedure prior to analysis was established, which consisted of extraction of G-1 from the ointment base by using n-hexane and dimethylsulfoxide as solvents, with a high percentage of recovery. Subsequently, the concentration of G-1 solution in dimethylsulfoxide (0,012 mg/mL) at 386 nm highest absorption wavelength was determined. The prospective validation was applied according to the present regulatory demands. Results: it was proved that the method was linear, precise, accurate and robust in the studied range. Conclusions: the results assure the reliability of the method for quantification of G-1 during the quality control.

Keywords : Furvinol; validation; spectrophotometry.

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