SciELO - Scientific Electronic Library Online

 
vol.48 número2Diseño de formulación de sulfato de cinc 10 mg Zn2+/5 mL solución oral para uso pediátricoValidación del método por espectrofotometría ultravioleta para control de calidad de clorhidrato de ciprofloxacina en tabletas Ciprecu índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista Cubana de Farmacia

versión impresa ISSN 0034-7515

Resumen

MARTINEZ ALVAREZ, Luis Octavio; ALEJO CISNEROS, Pedro; GARCIA PEREIRA, Reynaldo  y  CAMPOS VALDEZ, Doraily. Validation of the analytical method for sodium dichloroisocyanurate aimed at drinking water disinfection. Rev Cubana Farm [online]. 2014, vol.48, n.2, pp.191-198. ISSN 0034-7515.

Introduction: Cuba has developed the first effervescent 3.5 mg sodium dichloroisocyanurate tablets as a non-therapeutic active principle. This ingredient releases certain amount of chlorine when dissolved into a litre of water and it can cause adequate disinfection of drinking water ready to be taken after 30 min. Objective: developing and validating an analytical iodometric method applicable to the quality control of effervescent 3.5 mg sodium dichloroisocyanurate tablets. Methods: quantitation of the free active chlorine content in effervescent tablets by using a potentiometric method based on the platinum electrodes and the tittered 0.1 N sodium thiosulphate solution. The developed method was validated as per the category I parameters including the techniques for quantitation of the active principles in the finished forms. Additionally, other tests were conducted to evaluate the influence of the analyst and of the day on the analytical results. Results: the evaluated parameters in the validation of the method were within the set limits. The method was specific, linear, exact and precise in the range of studied concentrations. Conclusions: the results proved that this method can be used in a safe reliable way.

Palabras clave : free chlorine; effervescent tablets; sodium dichloroisocyanurate.

        · resumen en Español     · texto en Español     · Español ( pdf )