Abstract

ZIEGLER REGINATO, Fernanda; HAAS DA SILVA, Andreia Regina  and  DE FREITAS BAUERMANN, Liliane. Evaluation of the flavonoides use in the treatment of the inflammation. Rev Cubana Farm [online]. 2015, vol.49, n.3. ISSN 0034-7515.

Inflammation is considered a form of defense of our body and can be triggered by various stimuli. However, in certain situations the answer may be exacerbated and further, becoming harmful. The drugs currently used to treat inflammatory processes have adverse effects, vegetables compounds as an alternative to the use of these drugs. One of these compounds are flavonoids, which exhibit a number of pharmacological properties, especially the anti-inflammatory activity. For the execution of this study a survey was conducted in the databases Google Scholar, Scientific Electronic Library Online (SciELO) and Virtual Health Library (VHL), the time frame used in the research comprises the years 2008?2014 and the keywords used were flavonoids, inflammation, flavonoids in inflammation, inflammatory mediators and activity of flavonoids. The objective was to present different studies evaluating the activity of flavonoids in inflammation, emphasizing its action on specific chemical mediators such as cytokines, nitric oxide and arachidonic acid metabolites. The paper underlined the ability of flavonoids to modulate these chemicals. Quercetin, miricitrin, apigenin, epicatechin, and other flavonoids regulate the activity of enzymes and the synthesis of chemical mediators responsible for the activation and perpetuation of the inflammatory process, which is the main way to fight this disease.

Keywords : flavonoids; inflammation; anti-inflammatory activity; cytokines; nitric oxide; arachidonic acid metabolites.

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