SciELO - Scientific Electronic Library Online

 
vol.36 número1El comentario médico en las evoluciones de las historias clínicas: análisis crítico índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista Cubana de Medicina

versión impresa ISSN 0034-7523versión On-line ISSN 1561-302X

Resumen

FLORES GONZALEZ, Julia et al. Reacciones adversas durante el tratamiento de la urgencia hipertensiva. Rev cubana med [online]. 1997, vol.36, n.1, pp.11-17. ISSN 0034-7523.

A prospective, therapeutic and double blind assay was perfomed in 60 patients with clinical criteria of hypertensive emergency, the effectiveness, as well as the type and frequency of adverse reactions of clonidine hydrochloride were compared with the ones of nifedipine, a calcium antagonist, using a dosage of 0.15 mg and 10 mg, respectively, during a 3-hours observations period. The hypertensive emergency was controlled in 96.6 % of the group treated with nifedipine. More than 60 % of the casuistic group reported side effects, but with no clinical significance. A statistically significant differences was confirmed regarding the occurrence of headache with the use of nifedipine (p = 0,01), and the occurrence of drowsiness (p = 0,004) and xerostomia (p = 0,01) with the use of clonidine. There were no cases of symtomatic orthostatic hypertension. A greater number of cases presenting with asymptomatic orthostatic hypertension were found in the group receiving clonidine compared with the group receiving nifedipine (30 % vs 16 %), although there were no statistically significant differences. The sedative effects of alpha-2 agonist were common (63 %) but such effects neither interfere with the neurologic examination of the patients nor limited its therapeutic efficacy. No coronary or cerebral stokes occurred during the observation period.

Palabras clave : CLONIDINE [adverse effects]; NIFEDIPINE [adverse effects]; CLINICAL TRIALS; HYPERTENSION [chemotherapy].

        · resumen en Español     · texto en Español

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons