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Revista Cubana de Medicina

versão impressa ISSN 0034-7523versão On-line ISSN 1561-302X

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SOLER MOREJON, Caridad. Acidosis láctica. Rev cubana med [online]. 2000, vol.39, n.2, pp.115-119. ISSN 0034-7523.

It is know that lactic acid is a last product of glucose anaerobic metabolism, that, in normal conditions, serum levels reach 2 mEq/L or less. Most of lactate is released in a very efficacious way by liver and is used in gluconeogenesis or to obtain energy. If there are significant increases of serum lactate figures with a decrease of metabolism of the conversion of lactate in pyruvate, a situation of metabolic acidosis frequently serious will present, which may provoke death of patient. From the clinical point of view, it must be suspected in a patient with non well explained metabolic acidosis and a high anion gap, which is over 25-30 mEq/L, even in presence of renal failure, ketoacidosis or ingestion of a toxic agent. That prevention of tissue hypoxia play a very significant role and to this effect, all measures contributing to guarantee a good tissue perfusion. Importance of a appropiate control of diabetes mellitus, a rigurous selection of hypoglycemic agents, contribution of thiamine in risk patients, amongst other measures are emphasized

Palavras-chave : LACTIC ACID [metabolism]; DIABETES MELLITUS [therapy]; ACIDOSIS, LACTIC [diagnosis]; ACIDOSIS, LACTIC [therapy].

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