Resumo

DIAZ TORRES, Héctor Manuel et al. Marcadores de progresión serológicos y celulares en pacientes cubanos infectados por VIH-1. Rev cubana med [online]. 2001, vol.40, n.1, pp.10-16. ISSN 0034-7523.

The behavior of serologic and cell markers for disease progression in a group of Cuban serologically-confirmed HIV-infected patients was studied. Firstly, 228 subjects at different clinical stages were randomly selected. The level of antibodies to HIV-1 24 kd protein was determined in every case which were followed-up for 26.5 months to observe their clinical progression. At the beginning of the follow-up period, it was confirmed that 65 % of patients with minor opportunistic infections and 98 % of AIDS patients had low anti p24 antibody titers and that the clinical progression rate was significantly higher in the group of patients that entered the study with low titers or lack of detectable anti p24 antibodies. At the end of the follow-up period, a cross sectional study was performed on 100 of the 228 patients, which included determination of anti p24 antibody titers, p24 antigenemia detection and lymphocyte sub-population count through flow cytometry. There was a correlation among serologic tests, CD4+ cell counts and clinical staging. The reduction of anti p24 antibodies titers was seen as an early marker. The usefulness of the combined use of these markers in the clinical follow-up of those patients was pointed out

Palavras-chave : HIV; AIDS-RELATED OPPORTUNISTIC INFECTIONS; HIV INFECTIONS [diagnosis]; ACQUIRED IMMUNODEFICIENCY SYNDROME [diagnosis]; ACQUIRED IMMUNODEFICIENCY SYNDROME [microbiology]; SEROLOGIC TESTS; ENZYME-LINKED IMMUNOSORBENT ASSAY; DISEASE PROGRESSION; ANTIVIRAL AGENTS [therapeutic use]; CD4-POSITIVE T-LYMPHOCYTES; HIV CORE PROTEIN P24.

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