Abstract

GONZALEZ GARCIA, Verónica Marlene; FERNANDEZ MACHIN, Luis Manuel; RUIBAL LEON, Antonio J.  and  DURAN TORRES, Gilberto. Inhibidores de la enzima conversora de angiotensina: Revisión de estudios multicéntricos. Rev cubana med [online]. 2002, vol.41, n.5, pp.274-282. ISSN 0034-7523.

A literature review of the angiotensin inhibitors was made. A brief historical review was made and the mechanisms of actions, the effects at different levels and the secondary reactions of these inhibitors were reviewed. Different multicenter studies that have been carried out with this group of drugs were analyzed, in which we found out that such drugs favorably affect morbidity and mortality of patients with heart failure, their effects are higher in those patients with advanced degree of heart failure and that high doses should be used according to tolerance. Although it is said that these inhibitors are not exchangeable, the reviewed literature did not show the superiority of one drug over the others for certain disease and/or group of patients.

Keywords : ANGIOTENSIN-CONVERTING ENZYME INHIBITORS [history]; MULTICENTER STUDIES; INDICATORS OF MORBIDITY AND MORTALITY; CARDIOVASCULAR DISEASES [drug therapy].