Abstract

BENITEZ LLANES, Orestes; GOMEZ BARRY, Hilario; CASTANER MORENO, Juan  and  GUTIERREZ ROJAS, Ángela R.. Indicadores de predicción evolutiva en la glomerulosclerosis segmentaria y focal idiopática. Rev cubana med [online]. 2002, vol.41, n.6. ISSN 0034-7523.

A clinical evolutive and descriptive study of the patients with segmentary and focal idiopathic glomerulosclerosis (SFIGE) diagnosed between October 31st, 1988, and October 31st, 1999, was conducted. The following variables were analyzed: age, sex, race, presence of arterial hypertension, persistent proteinuria, level of serum creatinin on diagnosing the disease and of interstitial fibrosis in the histological study obtained by kidney biopsy (KB). The primary data were automatically processed by using the SPSS computer program to manage the database. It was observed that GESFI represented 7.5 % (26/346) of the KB performed, 11.3 % (26/230) of the primary glomerular diseases that were diagnosed and 20 % (14/68) of the cases with nephrotic idiopathic syndrome (NIS). The later was more frequently found in black patients or mestizoes (27.6 % vs 15.4 % in white subjects), in males (64.3 %) and in individuals under 30 (57.1 %). The average age of the patients was 37.7± 14.8; 61.5 % (l6/26) of the cases were males for a ratio of 1.6:1 in relation to females. There was no significant relation of arterial hypertension and proteinuria with kidney dysfunction, even though they were present in most of the patients. This relation was not found with age, sex and race, either. However, a significant (p < 0.05) and a very significant relation (p < 0.01) were observed with the level of creatinine on diagnosis and the presence of interstitial fibrosis, respectively. It was concluded that interstitial fibrosis and the level of creatinin on diagnosis were markers of bad prognosis in the evolution of this disease.

Keywords : GLOMERULOSCLEROSIS, FOCAL [genetics]; NEPHROTIC SYNDROME; DIAGNOSIS, CLINICAL; MALE; EPIDEMIOLOGIC STUDIES.