Resumo

BORROTO DIAZ, Gerardo; BARCELO ACOSTA, Malicela; GUERRERO DIAZ, Carlos  e  RODRIGUEZ ALONSO, Héctor. Frecuencia y factores de riesgo de la necrosis tubular aguda en el postrasplante renal inmediato. Rev cubana med [online]. 2002, vol.41, n.6. ISSN 0034-7523.

Acute tubular necrosis (ATN) is the most frecuent cause of renal allograft dysfunction in the immediate postransplantation period. To know frecuency and risk factors associated with its appearance, a study in 275 cadaveric donors renals transplantation was made. There was complication in the 40%, ( n= 110 ), of patients without statistical diference by sex. Age of recipients (42.36) and donors (37.46 years) was greaters in patients with ATN, where predominance of diabetes mellitus and high blood pressure, were the contributing pathology to renal failure as the basic disease. Also the use of ciclosporin A as profilactic treatment against rejection was a factor facilitating the ATN and extended it. Statistically significance were the cold ischemia times, similar or greaters within 24 h, where ATN was present in 63 % of cases with a mean duration of 19.62 days, and warm secundary ischemia times, similar or greaters of 60 minutes, with a frecuency of 92.6% and a mean duration of 20.5 days, compared with the times of the patients without ATN. There was the same situation with rejection, which was more frecuent (60.9% ) and early in the ATN patients, and the ischemic complication was longer in patient with both complications. The patients with ATN in the immediate postransplant period had a lower allograft survival than patients without ATN.

Palavras-chave : KIDNEY TUBULAR NECROSIS, ACUTE [etiology]; KIDNEY TRANSPLANTATION [adverse efects]; RISK FACTORS; GRAFT REJECTION.