Resumo

ARANGO PRADO, María del C.; FAXAS GARCIA, María E.; PEREZ DEHANAY, Yoselín  e  CAMACHO RODRIGUEZ, Rolando. Citotoxicidad natural inducida por la activación de linfocitos T en pacientes con cáncer de mama. Rev cubana med [online]. 2002, vol.41, n.6. ISSN 0034-7523.

The capacity of the soluble mediators released during the activation of T lymphocytes to potentiate the response of natural cytotoxicity was studied in a group of 12 patients with breast cancer (5, stage IIa; 2, stage IIb; 2, stage III; and 3, stage IV) This activation was performed with IORT3, IORT1, anti-CD3 and anti-CD6 monoclonal antibodies, respectively. As a result, it was observed a reduction of the cytotoxic activity of peripheral mononuclear cells induced by the mediators released during CD3/CD6 activation mainly among patients in the most advanced stages (III and IV), which differs completely from what was analyzed in sound controls and in most of the stage II patients.

Palavras-chave : BREAST NEOPLASMS [immunology]; T LYMPHOCYTES, CYTOTOXIC; ANTIBODIES, MONOCLONAL; KILLER CELLS, NATURAL.