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Revista Cubana de Medicina

Print version ISSN 0034-7523On-line version ISSN 1561-302X


ALVAREZ-GOMEZ, Juan A. et al. Precondicionamiento isquémico inducido por el ejercicio en pacientes con enfermedad coronaria. Rev cubana med [online]. 2003, vol.42, n.1, pp.52-57. ISSN 0034-7523.

14 patients, 9 males and 5 females, with ischemic heart disease demonstrated by coronariography or myocardial perfusion study and positive ergometric test were included in this study. All of them underwent 3 consecutive ergometric tests (Erg. 1, Erg. II and Erg. III) with an interval of 30 min between Erg. I and Erg. II and of 24 h between Erg II and Erg III. Significant differences were found between the means of Erg. I and II (p £ 0.01) and between Erg. I and III (p £ 0.5) in the following variables: duration of ischemia (434 s ± 228, 300 s ± 177, 314 s ± 226); depression of the ST segment (-2.9 mm ± 1.3, -2.1 mm ± 1.3, -2.2 mm ± 1.1); variation of the slope of the ST/FC relation (-507 mm/s ± 188, -360 mm/s ± 225, -402 mm/s ± 180); and between Erg. 1 and Erg. III (p £ 0.5) in the duration of angina (243 s ± 66, 172 s ± 109, 122 s ± 90). The double products in the variables measured increased in Erg. II and III compared with Erg. 1, but with no statistical significance p >.05. It was concluded that ischemia induced by exercise showed less evidence of ischemia at 30 min. A trend towards an ischemic reduction, although less intense, was also observed. The ischemic preconditioning may be the mechanism generating both cardioprotections.


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