SciELO - Scientific Electronic Library Online

vol.44 número1-2La amiloidosis como complicación de la anemia drepanocíticaClínica neurológica en pacientes infectados por el virus de la inmunodeficiencia humana en un país de África índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados



  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO


Revista Cubana de Medicina

versión On-line ISSN 1561-302X


HERES ALVAREZ, Flor de la C. et al. Autoimmunity, antinuclear antibodies, coronary heart disease, atherosclerosis. Rev cubana med [online]. 2005, vol.44, n.1-2, pp. 0-0. ISSN 1561-302X.

It has been suggested that autoimmunity plays a role in atherosclerosis. The aim of this paper was to determine wether a systemic autoimmune response, characterized by the presence of antinuclear antibodies (ANA), rheumatoid factor (RF) and alterations of serum immunglobulins (Igs), is associated with coronary atherosclerosis. The serum of 2 groups of patients was studied; 41 subjects with at least 50 % of stenosis in the 3 main coronary arteries (SCA) and 26 subjects with no evidence of coronary injuries (NECI) determined by coronary angiography. The antinuclear antibodies were determined by immunofluorescence in cryostatic sections of rat liver; the rheumatic factor by fixation in latex and the quantification of IgG, IgA and IgM by immunoturbidimetry. It was found that the frequency of autoantibodies detected in the SCA group proved to be similar to that of the NECAI group (ANA: 17 % vs. 15 %, p = 0,856; RF: 7 % vs. 4 %, p = 0,559). It was shown that the differences of the mean values of serum immunoglobulins between both groups of patients were not statistically significant (IgG: 12,4 g/L vs. 13,0 g/L; IgA: 3,6 g/L vs. 3,6 g/L; IgM: 1,2 g/L vs. 1,4 g/L; p = 0,328, p=0,946,p= 0.157, respectively). According to the results, it was concluded that the presence of ANA, RF and abnormal concentrations of serum Igs were not useful to identify individuals with advanced atherosclerosis.

Palabras clave : Autoimmunity; antinuclear antibodies; coronary heart disease; atherosclerosis.

        · resumen en Español     · texto en Español     · Español ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License