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Revista Cubana de Medicina

versión impresa ISSN 0034-7523versión On-line ISSN 1561-302X

Resumen

ARUS SOLER, Enrique; PEREZ BRIOSO, Nelson A.; PARRILLA DELGADO, María  y  DOMINGUEZ ALVAREZ, Carlos. Antifibrotic effect of recombinant interferon alfa 2b in liver cirrhosis caused by virus B or C. Rev cubana med [online]. 2005, vol.44, n.3-4. ISSN 0034-7523.

The antifibrotic effect of recombinant interferon alfa 2b used for a year (6 millions of U 3 times a week) in patients with liver cirrhosis caused by virus B or C was evaluated by histological studies and Doppler echography before and after concluding the treatment. The hepatic biochemical profile was assessed during that year. 10 patients participated in the research. In the global analysis of the morphometric method applied to the histological study and in the Doppler echography, it was found that there was no statistically significant reduction of liver fibrosis, but it individually decreased in 3of the patients treated and it stopped in one. The semiquantitative method for evaluating fibrosis in the liver biopsy did not show a reversion of the fibrotic process. A statistically marked improvement was observed in the aminotransferases. Adverse effects coinciding with what is reported in the national and international literature reviewed were detected.

Palabras clave : Liver cirrhosis; treatment; interferon; antifibrotic action.

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