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Revista Cubana de Medicina

versão impressa ISSN 0034-7523versão On-line ISSN 1561-302X


PINOL JIMENEZ, Felipe  e  PANIAGUA ESTEVEZ, Manuel. Neuropeptides and Helicobacter pylori in chronic gastritis. Rev cubana med [online]. 2006, vol.45, n.3. ISSN 0034-7523.

Nowadays, the Helicobacter pylori infection of the gastric mucosa is closely related to the gastric pathologies (acute gastritis, chronic gastritis, ulcer, cancer and gastric lymphoma), which obey to different physiopathological mechanisms that according to their intensity and persistence appear in the individuals infected by this microorganism. Among the proposed mechanisms that are altered during the infection we find the neuroimmune mechanisms of the stomach that loss their regulating and defending action of the mucosa and aggravate the damage initiated by the bacterium that is clinically traduced as ulcerous-like dyspeptic syndrome of gastritis. An updated review of the failures and presence of the neuroimmune substance taking part in the inflammatory process was made. It will allow clinicians, gastroenterologists and general physcians not only to search therapeutics capable to regulate the neuroimmune system before, during and after the infection to attain an adequate histic regeneration, but to improve the functional capacity of the stomach and to prevent the torpid evolution of the disease, at worst, once the Helicobacter pylori infection is diagnosed.

Palavras-chave : Neuropeptides; Helicobacter pylori; chronic gastritis.

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