Abstract

BORROTO DIAZ, Gerardo; GUERRERO DIAZ, Carlos; PONCE PEREZ, Pedro  and  LORENZO, Amaury. Is diabetes mellitus a genetically determined complication after a renal transplant. Rev cubana med [online]. 2006, vol.45, n.4, pp. 0-0. ISSN 1561-302X.

Diabetes mellitus appearing after renal transplant (PRTDM) is a frequent and multifactorial complication; however, it seems to exist an individual predisposition to develop such a disease. A study was conducted in 274 subjects that underwent renal transplantation (RT) from dead donors in “Hermanos Ameijeiras” Surgical Clinical Hospital to corroborate this hypothesis. It was found a frequency of PRTDM of 14.2 %, with a predominance of histocompatibility antigens (HLA), A28, 9/ 23.07 %, B8 l7/17.94 %, B18 5/12.82 %, and B27 3/7.5 %, in the patients with PRTDM that was statistically significant compared to the control group. A higher incidence of complication was observed in patients requiring RT due to polycystic renal disease l7/21 (33.3 %), and glomerulopathies 9/54 (16.6 %), as well as in those with family history of intolerance to carbon hydrates in 20.5 %, 8/39 of RT with PRTDM, and only in 5.9 %, 14/235 of the patients without PRTDM. These findings could be indirect signs that PRTDM is a genetically inherited complication appearing under the influence of other risk factors for its development

Keywords : Post renal transplant diabetes mellitus; risk factors; histocompatibility; genetical hypersensitivity; base disease.