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Revista Cubana de Medicina

versão impressa ISSN 0034-7523versão On-line ISSN 1561-302X

Resumo

RODRIGUEZ FERNANDEZ, Rolando et al. Primary sclerosing cholangitis in a patient with autoimmune panhypopituitarism: A case report. Rev cubana med [online]. 2008, vol.47, n.1. ISSN 0034-7523.

A case of a patient with diagnosis of autoimmune panhypopituitarism (vasopressinsensitivity diabetes insipidus, hyperprolactinemia, hypothyroidism, secondary hypogonadism and corticosuprarenal insufficiency) established 3 years ago, was reported. At the end of 2005, he began to present an acute pain in the epigastrium and right hypochondrium, accompanied with vomiting with food residual, high fever with chills, followed of choluria, acholia and greenish icterus, hepatomegaly, marked elevation of bilirubin, leukocyte alkaline phosphatase and gamma glutamil transpeptidase, leukocytosis, that required treatment with antibiotics by endovenous route and mimmicked, at the beginning, the diagnoses of choledocian lithiasis, pancreatic head tumor, and cholangiolitic hepatitis caused by drugs. These episodes were frequently repeated until the diagnosis of primary sclerosing cholangitis was made by retrograde endoscopic cholangiopancreatography and liver biopsy. Literature was reviewed, but no reports of association of primary sclerosing cholangitis with autoimmune panhypopituitarism were found.

Palavras-chave : Primary sclerosing cholangitis; autoimmune panhypopitiutarism; liver transplant.

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