Revista Cubana de Medicina
versão On-line ISSN 1561-302X
KOKUINA, Elena et al. Rheumatoid factor: association with the radiological erosion and with the rheumatoid arthritis activity. Rev cubana med [online]. 2008, vol.47, n.3, pp. 0-0. ISSN 1561-302X.
OBJECTIVE: to define the relation of the rheumatoid factor with the radiological articular erosion, the activity of the disease and the functional disability of rheumatoid artritis (RA). MÉTHODS: A cross-sectional study was conducted among 209 patients with RA. Of them, 74 with RA of short evolution (= 2 years). The following indicators were evaluated: RhF by latex agglutination (RhF-A), RhF by automated immunoturbidimetry (RhF-T), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Disease Activity Score 28 (DAS 28), functional disability index (Health Assessment Questionnaire score, HAQ), and the presence of radiological erosions. RESULTS: 77 % of the RhF-A positive patients and 73 % of the RhF-T positive patients presented radiological erosions in contrast with 38 % of the RhF-A negative patients (p<0.001) and with 14 % of the RhF-T negative cases (p<0.001). The mean RhF-A figures of the patients according to the 4 grades of articular affectation (maximum: > 6 eroded articulations; minimum: 0 erosion; < 6 swollen articulations) were 484, 162, 57 and 17 UI/mL (p<0.001), whereas those of RhF-T were 277, 185, 22 and 33 UI/mL (p<0,01). The positive predictive value (PPV) for the erosion of RhF-A >512 UI/mL was 92 %, and that of RhF-T >97 UI/mL was 96 %. The mean values of DAS28 in the RhF-A and RhF-T positive patients were 5.04 and 4.94, respectively. In the negative, these values were 4.26 and 3.97 (p<0.001 for both). The HAQ values were 1.31 and 1.29 in the RhF-A and RhF-T positive patients, respectively, while in the negative they were 0.99 and 0.89 (p<0.01 for both). Correlation was found between the RhF figures by both methods and those of ESR, CRP, DAS28 and HAQ (p<0.05 or p<0.01). CONCLUSIONS: High levels of RhF correspond with a higher degree of inflammation and articular destruction in the rheumatoid arthritis.
Palavras-chave : Rheumatoid factor; rheumatoid arthritis; radiological erosion; DAS28; HAQ; CRP; ESR.