Revista Cubana de Medicina
versão On-line ISSN 1561-302X
MARMOL SONORA, Alexander et al. Use superiority of polyclonal antibodies (Thymogan) in patients underwent to renal transplants in Nephrology Institute, 2003-2007. Rev cubana med [online]. 2009, vol.48, n.3, pp. 36-47. ISSN 1561-302X.
Introduction: It is a descriptive and observational and retrospective study to compare acute rejection incidence (AR), its classification (Banft 1997), and causes of grafts lost among three immunosuppression protocols. Methods: Cadaver donor renal transplants (116) were studied in "Dr. Abelardo Buch López" Nephrology Institute from 2003 to 2007. Were excluded those patients with loss of renal function or deceased from causes other than immunosuppression protocol used. Protocols compared were: I. Quadruple sequential with polyclonal antibodies (AcP, Thymogam). II. Quadruple sequential with monoclonal antibodies (AcM, IOR-T3), and III. Triple. Immunological variables analyzed were: HLA compatibility and percentage of anti-HLA antibodies and no-immunologic ones, as TR number, donor' age, death cause, cold ischemia, post-TR acute tubular necrosis, treatment extent (days) using biological therapies and collateral reactions. We used the frequency distribution and homogeneity test in qualitative variables analysis. In the quantitative ones SD and arithmetic mean were estimated and Kruskal Wallis test was used. Results: I protocol evidenced a lower incidence of the first RA crisis during the 1st year in spite of its use in patients with a great immunologic risk, unlike II and III protocols, where there were transplant losses in 22,2 % and 20,5%, respectively. When RA was present, severity was very lower in I protocol (25,0% suspected of RA and 75,0% RA IA) unlike the RAs in II and III protocols where also were RA IIA and IIb. Conclusions: Sequential quadruple protocol with AcP, Thymogan, has better results in our practice and it is ideal in patients with a mayor immunologic risk.
Palavras-chave : Renal transplant; polyclonal antibodies; acute rejection.