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Revista Cubana de Medicina

versión On-line ISSN 1561-302X


BORROTO DIAZ, Gerardo et al. Insulin resistance syndrome after renal transplantation. Rev cubana med [online]. 2010, vol.49, n.3, pp. 242-254. ISSN 1561-302X.

Insulin resistance syndrome (IRS) is a common multifactorial complication associated with unsatisfactory evolution of the renal graft and the patient. We conducted a case-control study of 81 patients with more than 1 year of transplantation and without a diagnosis of diabetes mellitus before it. The cases were patients with IRS by at least 1 of the 3 criteria used (NCEP-ATP-III, WHO and IDF) and the controls were those who did not present this complication. The objective of the study was to determine the frequency before and after renal transplantation, useful criteria for the diagnosis and impact on graft function. We obtained 48.1 % of patients with IRS, of whom 18 (22.2 %) had it from the stage before transplantation and 21 (25.9 %) developed it de novo. ATP III and IDF criteria diagnosed 31 patients (79.4 %), while the WHO criterion diagnosed only 41 %. The components of the syndrome with greater presence in the study sample were: high blood pressure, hypertriglyceridemia and abdominal obesity in descending order, which justifies the results obtained when applying the different diagnostic criteria. On comparing the intensity of glomerular filtration and plasma creatinine values according to the presence of IRS, it was found that IRS patients presented greater deterioration of graft function, though it was not statistically significant.

Palabras clave : Insulin resistance syndrome; renal transplantation; metabolic complications; renal function.

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