Revista Cubana de Medicina
On-line version ISSN 1561-302X
CASTELLANOS FERNANDEZ, Marlen Ivón et al. Special features of hepatocellular carcinoma in patients presenting with liver cirrhosis. Rev cubana med [online]. 2011, vol.50, n.1, pp. 57-69. ISSN 1561-302X.
Introduction: The liver cirrhosis (LC) is located among the leading causes of death in Cuba, one of its complications, the hepatocellular carcinoma (HCC) account for the death of these patients leading to an increase of the clinical interest by the diagnostic features and of treatment. Methods: An analytical, prospective and descriptive study was conducted in 203 patients presenting with LC in the Institute of Gastroenterology from 2005 to 2007. Sample included 105 men and 98 women aged 56,4 as average most of viral cause and in different stages of disease progression. The clinical characteristics and treatment criteria were assessed at diagnosis using descriptive statistical methods and the survival analysis was made using the Kaplan-Meier curves. Results: The presentation frequency of HCC was of 15.5 %, the more frequent cause associated with the chronic infection by hepatitis C prevailing in both sexes and in advanced ages. The was predominance of nodular lesions unique greater than 2 cm in the right liver lobule in the 77.7 % of the cases, associated with a portal hypertension. The 1 year survival was less than 45 %. Conclusions: The diagnosis of disease was made in stages where the alternatives of treatment and cure were scarces. The surveillance of HCC in patients presenting with LC is insufficient. The survival could to improve with an early diagnosis and the application of appropriate therapeutic options.
Keywords : Hepatocellular carcinoma; liver cirrhosis; hepatitis C virus.