Revista Cubana de Medicina
version ISSN 0034-7523
TORRES ODIO, Sylvia et al. Behavior of HLA-DQB1*02 and HLA-DQB1*03 alleles in patients with a presumptive diagnosis of celiac disease. Rev cubana med [online]. 2011, vol.50, n.3, pp. 279-288. ISSN 0034-7523.
The celiac disease (CD) is autoimmune and it is present in genetically predisposed subjects, characterized by the intolerance to determined proteins present in wheat, rye and barley: called gluten and gliadin. It is known that there is an association between HLA-system and celiac disease (HLA-DQ2/HLA-DQ8), but there aren't Cuban studies on this association, thus we analyzed the behavior of DQB1*02 and DQB1*03 alleles by means of an observational and analytical study in 65 patients with a presumptive diagnosis of celiac disease to include its detection in the diagnostic scheme of this complex disease. There was found that subjects carriers of the DQB1*02 allele (OR: 2,26) were more susceptible to suffer this disease than those non-carriers, that the 60% of the supposed patients presenting with the celiac disease had the HLA-DQ2 allele and the 3% had the HLA-DQ8 allele. We conclude that the HLA-DQ2/HLA-DQ8 genotyping is very useful for the diagnosis of the celiac disease.
Keywords : HLA; celiac disease; allele; genotyping.