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Revista Cubana de Medicina

versão impressa ISSN 0034-7523

Resumo

SOTO LAVASTIDA, Alexis; LARA FERNANDEZ, Gloria; MICHEL ESTEBAN, Enrique  e  LLIBRE GUERRA, Juan Carlos. Multisystem atrophy and diagnostic criteria updating. Rev cubana med [online]. 2011, vol.50, n.3, pp.322-332. ISSN 0034-7523.

The multisystem atrophy is a sporadic neurodegenerative disorder of unknown origin characterized by parkinsonism, cerebellar disorders, autonomic dysfunction and pyramidal disease, provoked by a cellular loss and gliosis in the nigrostriatal, olivopontocerebellar and autonomic neurons and the presence of oligodendroglia and neuronal intracytoplasmic positive inclusions, ubiquitin, tau and alpha-sinuclein affecting men and women starting as average during the sixth decade of life and a prevalence of 4/100 000. The last diagnostic criteria of multisystem atrophy were showed as well as the clinical case of a patient aged 65 with a progressive picture of 4 years of evolution, progressive cerebellar ataxia, a rigid akinetic syndrome autonomic dysfunction, pyramidal signs and a poor response to levodopa with magnetic resonance images showing vermis atrophy, cerebellar hemispheres, cerebral stem (bridge) and hipointensity of both putamen regions in T2. We conclude that case was diagnosed with type C multisystem atrophy.

Palavras-chave : Multisystem atrophy; strionigral degeneration; olivopontocerebellar atrophy; Shy Drager's syndrome; parkinsonism; alpha-sinucleinopathies.

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