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Revista Cubana de Medicina

versión impresa ISSN 0034-7523


QUESADA DORTA, Marlene et al. Cytogenetic results in patients with chronic myeloid leukemia. Rev cubana med [online]. 2011, vol.50, n.4, pp. 341-347. ISSN 0034-7523.

Introduction: The chronic myeloid leukemia is a myeloproliferative disease characterized by three progressive phases. Its cytogenetic analysis assessment allows us to verify the diagnosis and to establish the prognosis. Objective: To report the cytogenetic results from 180 patients clinically diagnosed with chronic myeloid leukemia and correlate them with the three phases of such neoplasia. Methods: The chromosomal analysis of bone marrow samples was performed using the techniques of G bands and the karyotypes were classified according to the criteria of the International System of Chromosomal Nomenclature. Results: The 94 % of study patients had the translocation t(9:22) more frequent in subjects in chronic phase (87,5 %). In contrast, the chromosomal anomalies secondary to Philadelphia chromosome were the more frequent ones in those cases in accelerated phase and of blast crisis (81.5 % and 96 %), respectively. Results obtained confirm the relation existing among the chromosomal alterations and the different evolution phases of chronic myeloid leukemia.

Palabras clave : Chronic myeloid leukemia; cytogenetic; secondary Philadelphia chromosome anomalies.

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