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Revista Cubana de Medicina

versão impressa ISSN 0034-7523versão On-line ISSN 1561-302X


GUERRA GONZALEZ, Alejandro et al. Metastasis: a milestone for knowledge, a challenge for science. Rev cubana med [online]. 2020, vol.59, n.1, e1167.  Epub 01-Mar-2020. ISSN 0034-7523.


Cancer metastasis is the transfer of tumor cells from one organ to another through a series of interrelated sequential multi-steps. This process is one of the main challenges in cancer treatment due to the biological heterogeneity. The metastasis process is considered the main cause of death in this disease, accounting for more than 90% of cancer deaths.


To identify the most recent advances on solid tumor metastasis and the association with epithelial-mesenchymal transition (EMT) in relation to the evolution and emergence of cancer.


A non-systematic review was carried out of the most significant studies on the subject, published in Web of Science, Pubmed, Ebsco, Scopus and Infomed.


Metastasis is the main cause of cancer death, so understanding the bases of the mechanism for metastatic tumor formation will allow for more effective therapies.

Palavras-chave : metastasis; cancer; mesenchymal epithelial transition.

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