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Revista Cubana de Medicina

versão impressa ISSN 0034-7523versão On-line ISSN 1561-302X


GONZALEZ-LOSADA, Cristóbal  e  LOZANO GARCIA, Mailyn. Neurological disorders associated with dengue virus infection. Rev cubana med [online]. 2020, vol.59, n.4, e1162.  Epub 15-Nov-2020. ISSN 0034-7523.


Neurological disorders associated with dengue is an issue of vital importance in these times because the clinical spectrum of dengue has changed and atypical manifestations are being reported much frequently. Serotypes 2 and 3 are the most frequently related to neurological manifestations such as encephalitis, myelitis and Guillain-Barré syndrome.


To report a series of cases with neurological disorders associated with DENV infection and its clinical, humoral and imaging variables.

Clinical case report:

All patients had, in the first instance, uncomplicated dengue clinical status due to 38.5º C fever and chills of sudden appearance, Cephalo-caudal maculo-papular rash that spares palms and soles, arthralgias, myalgias, frontal and retro-ocular headache, the latter due to the contraction of the superior rectus muscle of the eyeball. All confirmed with specific anti-dengue virus antibodies. One patient developed Guillain-Barré syndrome, another had encephalitis, bicytopenia, and compromised level of consciousness. The rest had transverse myelitis, meningoencephalitis and autoimmune encephalitis.


Neurological disorders associated with dengue virus should be suspected in every patient who is admitted with this infection and manifests any of the alterations described here.

Palavras-chave : dengue; neurological disorders; myelitis; encephalitis; Guillain-Barré syndrome.

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