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Revista Cubana de Medicina

versión impresa ISSN 0034-7523versión On-line ISSN 1561-302X


FERNANDEZ GARCIA, Sergio; RODRIGUEZ MARTINEZ, Kenia  y  BOFFILL CARBO, Suselys. Pleuropathy secondary to ovulation inducers. Rev cubana med [online]. 2021, vol.60, n.1, e1365.  Epub 25-Feb-2021. ISSN 0034-7523.


Pleural effusion is called the accumulation of fluid in the pleural space above 5 and 15 mL in a hemithorax. Different etiologies are responsible for its appearance but a group of them are given by drug etiology. Ovarian hyperstimulation syndrome is a secondary complication to the use of ovulation inducer therapy. The association of treatment with ovulation inducers in the genesis of pleural effusion is little known in the medical literature.


To review the most important clinical-pathophysiological aspects reported on pleurisy in ovarian hyperstimulation syndrome.


A review was carried out on the purpose of a clinical case of a 34-year-old patient with a medical history, followed in a fertility consultation. She was treated with clomiphene citrate and she developed an immediate moderate ovarian hyperstimulation syndrome. The clinical expression was a moderate right pleural effusion. Pleurisy is rare. It depends on the individual genetic predisposition of the patient and the susceptibility to drugs; the incidence varies between 0.6 and 10%. Different risk factors have been described, although any woman subjected to these treatments can develop it. Treatment is symptomatic, restoring the intravascular volume with the administration of crystalloids and / or albumin.


The association of ovarian hyperstimulation syndrome and pleuropathy secondary to treatment with clomiphene citrate is not frequent.

Palabras clave : pleural effusion; ovarian hyperstimulation; inducers of ovulation.

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