Introduction:

Sepsis is an inflammatory response of the body to an infection. Currently it continues as a major cause of morbidity and mortality worldwide. Early fluid administration is a fundamental strategy in the management of sepsis. However, the amount and type of fluids administered in patients with sepsis is still a matter of debate.

Objective:

To evaluate the results of randomized clinical trials for a deeper understanding of the effectiveness of fluid restriction in patients with sepsis.

Methods:

A systematic search was carried out in different databases to carry out a critical evaluation of the included articles, the Cochrane risk of bias assessment tools and data analysis were used.

Results:

Thirteen randomized controlled trials were included, which compared fluid restriction versus fluid administration in adult patients with sepsis.

Conclusions:

We found that fluid restriction was associated with a reduction in mortality and a lower number of days of respiratory and cardiovascular support in patients with sepsis. However, some studies found no significant difference in mortality between fluid restriction and fluid administration.

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