Abstract

FERRER MONTOYA, Rafael; VAZQUEZ ESTRADA, Alina de la C.; FORTUN DE SOTO, Thorvald  and  FERRANDIZ GUERRA, Sara. Niveles de inmunoglobulinas IgA e IgM en recién nacidos y correlación con infección congénita. Rev Cubana Pediatr [online]. 1998, vol.70, n.1, pp.11-16. ISSN 0034-7531.

A prospective analytical study of IgM and IgA inmunoglobulin levels of 600 neonates and their correlation with congenital infection risks was made. 10 neonates (1.7 %) presented a high IgM level whereas 18 (3 %) had a raised IgA level. A good correlation (OR) and statistical significance of raised IgA and IgM levels were found in newborns of mothers who had had hot and/or fetid amniotic fluid; ruptured membranes for over 24 hours and intralabor fever. Good correlation and statistical significance of high Igs were also present in neonates affected by bronchopneumonia and general congenital sepsis. As to the bacteriological cultures, good correlation and statistical significance was found in hemoculture and pharyngeal exudate, as well as raised Igs levels, and gastric residues with high IgM level. Gram-positive and gram-negative bacteria isolated from newborns presented good correlation (OR) and statistical significance, except for IgA in gram-negative bacteria. The four neonates who died from congenital infection had raised IgM levels.

Keywords : FETAL BLOOD [inmunology]; IgA [blood]; IgM [blood]; INFECTION [congenital].

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