Revista Cubana de Pediatría
On-line version ISSN 1561-3119
VELAZQUEZ ACOSTA, Juan Carlos. Principales protagonistas de la respuesta inflamatoria a la infección. Rev Cubana Pediatr [online]. 1998, vol.70, n.2, pp. 84-91. ISSN 1561-3119.
A review of the main elements involved in the inflamatory response of the individuals to infection is made, taking into account that this knowledge helps to improve the therapeutic management of patients. The main agents of inflammation are reviewed, starting from detonators such as: lipopolysaccharides, petpidoglycans, muramic acid to the principal mediators involved. The activation process of monocytes and endothelial cells is dicussed, as well as its repercussion. A dynamic analysis of the activation process according to the time elapsed since the onset of the infection and of its physiopathological stages is made. It is demonstrated the fundamental role played by the organism in the damage produced by the response to infection, and the importance of an adequate balance between proinflammation and contraregulation for the patient´s prognosis, which makes it necessary at the time of treatment.
Keywords : : SYNDROME SEPSIS; LIPOPOLYSACCHARIDES; PEPTIDOGLYCAN; MURAMIC ACIDS.