Abstract

CARDENAS GUIRAUDY, Aida et al. MIGRAINE: CLINICOGENETICAL STUDY IN CHILDREN AND ADOLESCENTS. Rev Cubana Pediatr [online]. 2005, vol.77, n.1, pp. 0-0. ISSN 1561-3119.

50 children and adolescents under 15 of both sexes that received medical attention at the Neurology office of “William Soler” Teaching Pediatric Hospital from May 2002 to April 2003, were studied. They were diagnosed migrane and had family history of the disease.Once migrane was classified, they were referred to the Genetics office of the hospital, where genealogy was investigated, and the inheritance pattern, as well as the source, maternal or paternal, of the disease were determined in each patient. There was a slight predominance of females (56 %) in the studied sample. Common migrane was the most frequent (86 %). There were 6 patients with classical migrane (12 %) and a patient with familial hemiplegic migrane. The precipitating factors referred to by 92 % of the cases were similar to those reported by literature. The hereditary pattern in most of the patients and independently of the type of migrane, was the dominant autosomal (98 %). A reduced penetrance was observed in 14 %. In a patient, inheritance was multifactorial (2 %). The maternal source was the commonest (84 %).

Keywords : Common migrane; classical migrane; family hemiplegic migrane; dominant autosomal inheritance; polygenic or multifactorial inheritance; mitochondrial inheritance.