Revista Cubana de Pediatría
On-line version ISSN 1561-3119
POZO LAUZAN, Desiderio and POZO ALONSO, Albia J.. Some considerations in relation to the new generation antiepileptic drugs in childrenSome considerations in relation to the new generation antiepileptic drugs in children. Rev Cubana Pediatr [online]. 2005, vol.77, n.2, pp. 0-0. ISSN 1561-3119.
The objective of this paper is to review the main second generation antiepileptic drugs and their administration in children: vigatrine, felbamate, lamotrigine, topiramate, tiagabine, oxcarbazepine, zonisamide, leventiracetam and stiripentol. At the beginning, they were recommended in adult patients with focal refractory epilepsies; however, their efficacy in different types of seizures in children has been proved for some years. Lamotrigine and topiramate are considered drugs of wide spectrum. Emphasis is made on metabolism, routes of elimination, indications, doses in children, drug interactions and side effects of the second generation antiepileptic drugs. Some of the new drugs that are currently under study as antiepileptic and that constitute a third generation, are mentioned.
Keywords : Antiepileptic drugs; refractory epilepsy; side effects.