Revista Cubana de Pediatría
versão On-line ISSN 1561-3119
MENA MIRANDA, Vivian R. et al. Metabolic disorders associated with sepsis: Proteins, lipids and carbohydratesMetabolic disorders associated with sepsis. Proteins, lipids and carbohydrates. Rev Cubana Pediatr [online]. 2005, vol.77, n.2, pp. 0-0. ISSN 1561-3119.
To guarantee the organic vital function normally offered by diet absorption it is necessary to have an adequate energy substrate to maintain homeostasis. When diet is not appropriate, the organism resorts to alternative sources to obtain energy given by glyconeogenesis, lipolysis and cetogenesis. Sepsis is associated with the interruption of these provisional sources of energy substrates. The function of the glucolytic pathway, whose integrity is necesary to adequately use glucose in the obtention of energy is affected during sepsis. All these anomalies together with the interruptions of the intracellular energy- producing machine (glucolytic enzymes, glyconeogenesis and mitochondrion) bring about a reduction of intracellular triphosphate adenosine that undermines all the cellular energy-consuming functions, including the formation of energy substrates (failed glyconeogenesis), the antioxidant production and the calcium homeostasis. Likewise, it is known that the increase of the levels of intracellular calcium activates potentially destructive enzymatic pathways, which reduce even more the cellular function and manage to cause death at this level. Thus, the accumulation of intracellular calcium may play an important role in the progression of early sepsis to a multiple organ failure, the most frequent cause of mortality at the intensive care units.
Palavras-chave : Sepsis; cellular energy; aerobic metabolism; anaerobic metabolism; mitochondrion.