Revista Cubana de Pediatría
versão On-line ISSN 1561-3119
GARCIA CABREJA, Alexander et al. Dyslipidemia and microalbuminuria in children presenting with type 1 diabetes mellitus. Rev Cubana Pediatr [online]. 2009, vol.81, n.1, pp. 0-0. ISSN 1561-3119.
INTRODUCTION: Type 1 diabetes mellitus is an autoimmune disease characterized by absolute deficiency of insulin production, glucose-metabolism disturbances, lipid, and proteins. The aim of present research was to know relation between dyslipidemia and diabetic renal injury, expressed by presence of microalbuminuria. METHODS: Fifty two children presenting with Type 1 diabetes mellitus, aged 9-15, and a disease length of 2 years or more. In all we carried out fast lipidogram including triglyceride analysis, total cholesterol, and low- and high-density lipoprotein cholesterol. Microalbuminuria tests were performed by means of radioimmunoassay for urine-human albumin and also glomerular filtration. RESULTS: There was dyslipidemia in 30 patients (57%) and decrease of high-density lipoprotein cholesterol in all patients dyslipidemic. We verified an increase of low-density lipoprotein cholesterol in 27 cases (51,6%); total cholesterol was high in 12 (23%), and there was hypertriglyceridemia only in 4 patients (7,6%). Twenty one of 30 dyslipidemic children (70%) had microalbuminuria. It was found that patients presenting with dyslipidemia had a greater percentage of microalbuminuria, but this one was not significant. All patients presenting with dyslipidemia there was a decrease of high-density l lipoproteins cholesterol. Dyslipidemia had a positive relation with length of diabetes, but not with sex. CONCLUSIONS: In Type 1 diabetes mellitus, total cholesterol and triglycerides there is a lack of enough information, and it is necessary to perform studies on high-density lipoprotein cholesterol to predict a future renal injury. Glycemia and lipid control is important to prevent, postpone or to improve the diabetic renal injury.
Palavras-chave : Type 1 diabetes mellitus; dyslipidemia; microalbuminuria.