Resumo

RIVERO GONZALEZ, Marlen; CABRERA PANIZO, Raquel; GARCIA GARCIA, Alina  e  DE LEON OJEDA, Norma Elena. Primary hypothyroidism in patients with Down syndrome. Rev Cubana Pediatr [online]. 2012, vol.84, n.2, pp. 146-154. ISSN 0034-7531.

Introduction: hypothyroidism is the resulting clinical picture of a reduction in the biological activity of thyroid hormones due to their low production or little use. Its association with Down syndrome has been previously described by other authors; however, few studies on the frequency of association of both entities in Cuba and on the clinical form of hypothyroidism in these patients have been conducted. Objectives: to evaluate the association of Down syndrome and hypothyroidism in patients seen at our service from January to December 2011. Methods: twenty four patients with Down syndrome, aged 3 to 7 years, were attended at the endocrinology service of "William Soler" pediatric hospital. Results: it was found that all these patients exhibited high values of hypophysial thyrotrop hormone, 18 had osseous age retardation (75 %) and 4 showed low size of less than 3 percentiles (16.6 %). Conclusions: hypothyroidism is a frequent disease associated with Down syndrome, so its detection and early treatment in these children is of vital importance to improve their cognitive development and integral growth.

Palavras-chave : hypothyroidism; Down syndrome.

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