Resumen

MOREDO ROMO, Edelisa  y  PASTRANA FUNDORA, Fernanda María. Experiences in treating infantile hemangiomas with Cuban-made propranolol. Rev Cubana Pediatr [online]. 2014, vol.86, n.2. ISSN 0034-7531.

Introduction: infantile hemangiomas are the most frequent tumors in children. Although they are generally benign, its fast growth may turn them into life-threatening destructive tumors in roughly 1 % of cases. At present, betablockers such as oral propranolol have been used with very good results. Objectives: to evaluate the effects and safety of Cuban-made propranolol for the treatment of infantile hemangiomas in proliferation phase. Methods: descriptive applied study of 21 patients with 26 infantile hemangiomas in proliferation phase. It was conducted from December 1st 2010 through June 31st 2012. The patients had been seen at the dermatology department of "Juan Manuel Márquez" teaching pediatric hospital and treated with Cuban-made orally administered propranolol at 2 mg/kg/day divided into 2 sub-doses. They were evaluated every 15 days up to the third month of treatment and monthly up to the 6 months of treatment. Adverse effects were recorded. Results: few days after the beginning of the treatment, the positive effect was evident in all the cases (favorable changes in staining or size). The adverse effects were slight and self-limited. The response to treatment was good or excellent in 99 % of patients after 6 months of treatment. Conclusions: the treatment with Cuban-made orally administered propranolol induces rapid improvement of infantile hemangiomas in these children, considerably shortening the natural evolution of these tumors with low secondary effects.

Palabras clave : hemangiomas; angiomas; propranolol; betablockers; childhood..

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