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Revista Cubana de Pediatría

versão impressa ISSN 0034-7531versão On-line ISSN 1561-3119


SILVERIO GARCIA, César Emilio et al. Clinical and epidemiological pattern of biliary atresia in Cuba. Rev Cubana Pediatr [online]. 2018, vol.90, n.4, e413. ISSN 0034-7531.


Biliary atresia is an infrequent colangiopaty that it is present in newborns among the second and the forth weeks of life.


To determine the clinical and epidemiological pattern of biliary atresia in Cuba.


Descriptive study in the population presenting biliary atresia (n= 30) attended in “William Soler” Hospital (from January, 2011 to December, 2015). Clinical and humoral features, and epidemiological variables were measured by an incidence analysis (per 1 000 live births) and statistical tests with significance of p<0,05.


Incidence in Cuba is of 0.47 x 10 000 live births (1: 21 078 live births); in Mayabeque province, it is registered the highest incidence 1: 6 784. All the patients presented icterus and 96.7 % presented choluria. High concentrations of total bilirubine (mean= 184.9 µmol/L), slight increase of alaninoaminotransferasa (mean= 201.8 U/L) and aspartatoaminotransferasa (mean= 27.5 U/L) than in the alcaline fosfatase (mean= 1 557.1 U/L); and cholesterol increase (6.8 mmol/L) with normal triglycerides were present. 70 % of the patients that underwent surgeries before reaching 60 days of life could reestablish the biliar flow. 35 % did not achieve this while underwent a surgery after 60 days of life.


The incidence of this disease is increasing in Cuba, not having gender preferences and it is higher in Mayabeque province. Manifestations of icterus, choluria, hyperbilirubinemia, light hypertransaminasemia, hypercholesterolemia with gammaglutamiltransferasa alteration higher than alcaline fosfatase, and the reestablishment of the biliary flow in patients being operated before the 60 days of life, are common.

Palavras-chave : biliary atresia; colangiopaty; neonatal cholestasis; icterus.

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