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Revista Cubana de Pediatría

versión impresa ISSN 0034-7531versión On-line ISSN 1561-3119


ACOSTA TORRES, José; PEREZ CUTINO, Maité; RODRIGUEZ PRIETO, Magela  y  MORALES GONZALEZ, Alejandro. COVID-19 in Pediatrics: clinical and epidemiological aspects, immunopathogenesis, diagnostic and treatment. Rev Cubana Pediatr [online]. 2020, vol.92, suppl.1, e1152.  Epub 20-Jul-2020. ISSN 0034-7531.


The World Health Organization declared as a pandemic the infection by the coronavirus called SARS-CoV-2 on March 11th, 2020 that emerged in the last days of 2019 in the Chinese province of Wuhan. The disease produced by this coronavirus it is called COVID-19 and it is an entity that has shown low morbidity and mortality in pediatric patients.


To examine epidemiological factors, symptomatology, diagnostic and treatment of the disease in pediatric ages.


It was reviewed literature using PubMed database to identify articles published until April 30th, 2020, and also reports, series of cases and laboratory data.


The most frequent onset age was in patients older that 5 years, having 2,5% of seriously ill patients with fever, cough, nasal congestion, dyspnoea, vomiting and diarrhea as the most frequent symptoms. Laboratory data indicated a mean of leukocyte count between 6,1 and 6,8 x 105, lymphopenia with a range between 2,5 and 40%, and an increase of alaniltranferase and creatininfosfoquinase enzymes, in addition to the C reactive protein anti-inflammatory marker with concentrations between 17 and 62,5%. Vertical transmission has not been verified. The most frequently used treatment is Lopinavir/ ritonavir and interferon. Chest X-ray was normal in the 20 to 66 % of the cases. No deaths were recorded in the six series of cases reviewed.

Final considerations:

The infection by SARS-CoV-2 in pediatric ages evolves with a favorable prognosis but more researches on the topic are needed for a best knowledge of this entity.

Palabras clave : coronavirus; COVID-19; SARS-CoV-2; cytokines; retrovirals.

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