Abstract

NODA ALBELO, Amauri Lázaro; CASTRO PACHECO, Berta Lidia; LOPEZ GONZALEZ, Lissette del Rosario  and  ROBAINA CASTELLANOS, Gerardo Rogelio. Multisystem inflammatory syndrome related to COVID-19 in children. Rev Cubana Pediatr [online]. 2020, vol.92, suppl.1, e1202.  Epub July 20, 2020. ISSN 0034-7531.

The clinical manifestations of the infection by SARS-CoV-2 are less frequent and severe in children than in adults; however, recent publications suggest the possibility of a severe clinical picture called multisystem inflammatory syndrome which is caused by the infection with coronavirus in pediatric patients. The objective of this work is to examine the aspects related to the epidemiology, pathogenesis, clinical presentation, diagnosis and treatment of the multisystem inflammatory syndrome in children. This syndrome has a post-infection nature and its physiopathology is probably the result of an abnormally organized activation of the immune system, in a genetic context of predisposition and activated by the peculiar biology of the SARs-CoV-2.The clinical characteristic of the affected patients include constant fever, affectation of multiple organs and systems, and positive results of inflammatory markers, and in addition meeting the criteria of recent or concurrent infection by SARS-CoV-2. For the treatment, apart from the measures of vital support and the use of antibiotics in the initial stage, it is recommended the use of specific immunomudolatory therapies, as intravenous immunoglobulin and steroids; as well as acetylsalicylic acid. The right approach to this entity requires maintaining a high level of alerts, with a clear definition of the suspected cases, the multidisciplinary participation and the implementation of an immediate therapeutic strategy.

Keywords : SARS-CoV-2; COVID-19; Kawasaki; multisystem inflammatory syndrome; shock; endovenous gammaglobuline.

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