Abstract

DELGADO, Jorge et al. Malondialdehyde and birth weight in preeclampsia: Brief review and association between them. Rev Cubana Obstet Ginecol [online]. 2008, vol.34, n.3. ISSN 0138-600X.

The hypertensive disorders of pregnancy (HDP) cause frequent perinatal morbidity and mortality in the world and in Cuba and they have been linked with oxidative stress. OBJECTIVES: to determine the evolutive characteristics of the concentrations of malondialdehyde in healthy pregnant women between 16 and 20 weeks (MDA 1) and = 36 weeks (MDA 2), the characteristics of the plasmatic concentration of malondialdehyde [MDA] determined in the sample of the preeclamptic women (SPE) on admission compared with healthy pregnant women (MDA 2), as well as the association of MDA concentrations with birth weight in preeclamptic patients (PE). METHODS: The MDA concentrations were calculated in 25 pregnant women according to inclusion criteria. Statistics: Means and standard deviations were determined by comparing the results of the MDA concentrations (Mann-Whitney, CI: 94 %, p< 0.06). Age, BMI, diastolic and mean arterial pressures, parity and birth weight were analyzed (Kruskall-Wallis, CI: 95 %, p< 0.05). Place: Department of Special Research of "Dr. Luís Díaz Soto" Hospital. Period: January 2004-January 2007. RESULTS: MDA concentrations were higher in M2 in comparison with the samples M1. MDA concentrations in preeclamptic patients (SPE) (n= 15) > MDA concentrations in healthy pregnant women (n= 10) (M2). The MDA concentrations (SPE) were inversely correlated with birth weight in the preeclamptic patients. CONCLUSIONS: MDA concentrations were significantly higher (p < 0.06) in the controls between M1 and M2. Birth weight was inversely correlated with MDA concentrations (SPE) in the preeclamptic patients when it was compared with what happened in the healthy pregnant women. It is necessary to go deep into the study of oxidative stress in preclampsia in order to increase its understanding and to design intervention strategies to reduce its effects.

Keywords : Oxidative stress; birth weight; malondialdehyde; free radicals; antioxidants; preeclampsia.

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