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Revista Cubana de Obstetricia y Ginecología

versión impresa ISSN 0138-600Xversión On-line ISSN 1561-3062


CALDERIN BOUZA, Raúl Orlando; YANES QUESADA, Miguel Ángel; YANES QUESADA, Marelis  y  LUGONES BOTELL, Miguel. Insulin resistance syndrome and polycystic ovary syndrome, are they related?. Rev Cubana Obstet Ginecol [online]. 2009, vol.35, n.1. ISSN 0138-600X.

Since the insulin resistance syndrome or X syndrome was identified by Gerald M. Reaven in his brilliant lecture for Banting´s medal in New Orleans, it has comprised several names and concepts. This syndrome is characterized by insulin resistance condition (IR), hyperinsulinemia and chronic inflammation and defines a metabolic condition causing a reduction in the ability of the human being to respond to physiological concentrations of insulin hormone in addition to present chronic inflammation. The insulin resistance syndrome is associated to metabolic alterations such as pre-diabetes and diabetes mellitus type 2 (DM2), dyslipidemia, blood hypertension and risk of developing cardiovascular diseases. Also, altered hemostasis, central adiposity, non-alcoholic fat liver, cancer and hyperuricemia are elements included in this syndrome nowadays. Additionally, insulin resistance found in girls prior to menarche is involved in the pathogenesis of polycystic ovary syndrome (POS) that is a disorder characterized by menstruation irregularities and excessive amount of androgens. Insulin resistance syndrome is a predominant disorder whose pathogenesis is influenced by genetic and environmental factors. Excessive intake of calories together with lack of exercising leads to phenotypical expression of this syndrome in individuals with genetic predisposition. This article emphasized the relationship of the metabolic syndrome and the polycystic ovary syndrome from the clinical, physiopathological, epidemiological and preventive viewpoints.

Palabras clave : insulin resistance syndrome; insulin resistance; polycystic ovary syndrome.

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