SciELO - Scientific Electronic Library Online

 
vol.45 número3Insuficiencia cervical y prolapso de bolsa amniótica “en reloj de arena”en gestante pretérminoTrastornos del espectro de placenta acreta índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista Cubana de Obstetricia y Ginecología

versión impresa ISSN 0138-600Xversión On-line ISSN 1561-3062

Resumen

HEREDIA RUIZ, Danay; HERRERA MARTINEZ, C. Manuela  y  FERNANDEZ CARABALLO, Douglas. Cellular Signaling Pathways Involved in Cervical Carcinogenesis. Rev Cubana Obstet Ginecol [online]. 2019, vol.45, n.3, e491.  Epub 01-Sep-2019. ISSN 0138-600X.

Introduction:

Human papillomavirus is considered a key factor in the development of uterine cervical lesions. However, infection per se is not enough to develop all carcinogenic events, so that these could be regulated by cell signaling pathways. The signals transmitted into the cell are produced through signaling cascades, which involve numerous proteins that gain and, or lose their biological activity, thus regulating the metabolism, transcription and translation of genes.

Objective:

To provide updated information on TLRs, Wnt / β-catenin and PI3K / Akt signaling pathways involved in cervical carcinogenesis.

Methods:

A review of specialized literature was carried out through original articles and reviews published in PubMed, Google Scholar, EBSCO databases and NCBI websites, in Spanish and English languages.

Results:

TLR pathway was found to play a key role in the fight against viruses, bacteria and other infections, as well as having antitumor immune activity. The Wnt / β-catenin pathway participates in several biological processes such as cell differentiation, migration and adhesion, while PI3K / Akt is related to cell growth, motility and survival.

Conclusions:

The activation or deregulation of some components of these pathways are involved in uncontrolled proliferation of tumor cells, an important event in cervical carcinogenesis.

Palabras clave : signaling pathways; TLRs, Wnt / β-catenin; PI3K / Akt; cervical carcinogenesis.

        · resumen en Español     · texto en Español     · Español ( pdf )