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Revista Cubana de Medicina Militar

Print version ISSN 0138-6557On-line version ISSN 1561-3046


MULET PEREZ, Agustín et al. Acute viral hepatitis C: treatment with high dose of human recombinant alpha 2b interpheron (Heberon alfa R). Rev Cub Med Mil [online]. 2009, vol.38, n.1. ISSN 0138-6557.

INTRODUCTION: For the treatment of acute viral hepatitis C, a number of therapeutic regimes with Interferon has been put forward. This paper presented our own experience in the application of a therapy different from the Standard treatment recommended in Cuba, which consisted of the parenteral administration of 3 million doses of recombinant Interferon Alpha 2b three times a week for 6 months. METHODS: The medical records of two patients, who were diagnosed with acute viral hepatitis C on the basis of clinical and epidemiological data, humoral alterations and positive viral markers, were reviewed, using histological diagnosis in one of them. They were administered 5 million Heberon Alpha R subcutaneously for 4 weeks and then additional 5 millions using the same way of administration three times a week to complete 6 months of treatment. RESULTS: Two months after finishing the treatment, the patients remained asymptomatic, gluthamic-piruvic transaminase scores were normal and Virus C RNA proved to be negative after evolving PCR. CONCLUSIONS: The therapy used in these patients proved to be effective, so it is recommended to treat acute viral hepatitis C.

Keywords : acute hepatitis C; treatment; recombinant interferon alpha..

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