Resumo

MULET PEREZ, Agustín et al. Adverse effects of treatment with the recombinant human type 2b alpha Interferon and rivabirine in patients presenting with chronic hepatitis C. Rev Cub Med Mil [online]. 2011, vol.40, n.1, pp.76-84. ISSN 0138-6557.

INTRODUCTION: The treatment of chronic hepatitis C is still a challenge. The combination with the better results is that of interferon with ribavirin, but it may to create adverse effects including difficulties to follow the treatment which on occasions, even to oblige us to suspend it. OBJECTIVE: To identify the adverse reactions to treatment with the combination of interferon and ribavirin. METHODS: A study was conducted in 13 patients presenting with chronic hepatitis C seen during 2006 and 2007 in the specialized consultation of the "Vladimir Ilich Lenin" University Hospital treated with human recombinant alpha-2b interferon (Heberviron). RESULTS: Fever, headache, chills, asthenia, myalgias and arthralgias were the more frequent adverse effects, as well as digestive symptoms: anorexia, nauseas, epigastralgia and the psychic type: depression, and hematologic type: anemia and leukopenia. Also, there was a hypothyroidism associated with a rheumatoid picture in a patient being necessary to suspend the treatment, as well as in another presenting with thrombopenia and another one with leukopenia. CONCLUSIONS: Prescribing the treatment with Heberviron in the patient with chronic hepatitis C, we must to take into account the frequency and magnitude of side effects, since it may be to interfere with fulfilment of and with the response to treatment and also to create a negative impact in the quality of life of patients.

Palavras-chave : Chronic hepatitis C; treatment with interferon and ribavirin; Heberviron; adverse effects.

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