ALONSO MARTINEZ, Maylin et al. Progression of metabolic deterioration in first and second degree relatives of type-2 diabetic patients. []. , 41, 4, pp. 370-378. ISSN 0138-6557.

Introduction: the onset of type-2 diabetes mellitus proceeds several years from the clinical diagnosis and it is associated with atherogenic risk factors and family history of this disease. Objective: to identify the presence and evolution of such factors, and carbohydrate metabolism disorders in relatives of diabetic patients. Methods: a cohort study in 113 subjects, first-and second-degree relatives of patients who have type-2 diabetes and who had no known disorders of glucose metabolism. Twice a year, blood pressure, body mass index, lipid profile, blood glucose (fasting and postprandial), insulin and insulin resistance were measured. Results: high mean values were found for body mass index, blood pressure and lipids, which increased in an evolutionary form. 90 new patients were diagnosed with disorders of this metabolism and a progressive deterioration of glucose metabolism; insulin resistance and insulin secretion were showed. Conclusions: the first-and second-degree relatives of patients with type-2 diabetes have a high prevalence of atherogenic risk factors, and they evolve into progressive deterioration of these factors and glucose homeostasis.

: type-2 diabetes mellitus; insulin resistance; hypertension; dyslipidemia; obesity; glucose tolerance test.

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