Abstract

RIO VAZQUEZ, Vicente; SALDANA BERNABEU, Alberto  and  MARTINEZ PEREZ, Alicia. Cardiovascular physiopathological mechanisms in patients with sleep deprivation. Rev Cub Med Mil [online]. 2013, vol.42, n.2, pp.210-220. ISSN 0138-6557.

There are many factors which are related to work, nutritional and hygienic habits and lifestyle that influence on sleep duration and bring about disequilibrium in the body homeostasis and lead to the appearance of risk factors that increase morbidity and mortality due to cardiovascular diseases. This work is aimed at updating and synthesizing the cardiovascular physiopathological mechanisms in patients with partial or total sleep deprivation. To achieve this aim, we consulted electronic databases (Pubmed, Ebsco, Medline and Hinari), and selected articles about the topic which have been published during the last five years. We found a significant association between sleep deprivation and cardiovascular diseases, explained by different mechanisms which include: autonomic disequilibrium with prevalence of sympathetic activity, increase of circulating catecholamines, diminished baroreflex sensitivity, low levels of intracellular magnesium, inhibition of melatonin secretion, and the action of diverse inflammation precursors. We conclude that, these mechanisms produce an increase in the vascular tone and high blood pressure among other variations that increase cardiovascular risk factors, morbidity and mortality.

Keywords : sleep deprivation; cardiovascular diseases; inflammation precursors; sympathetic activity.

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